False-negative immunoassay results for cardiac troponin I probably due to circulating troponin I autoantibodies.
نویسندگان
چکیده
منابع مشابه
بررسی تروپونین I در بیماران هیپوتیروئید مراجعه کننده به درمانگاه غدد بیمارستان حضرت رسول اکرم(ص)، انیستیتو غدد داخلی و متابولیسم
Background: With increase in the age there is an increase in both the incidence of hypothyroidism and cardiovascular diseases. We wanted to see whether hypothyroidism caused false positivity in patients who did not have cardiovascular problems or not. In hypothyroid state, creatine kinase leaks into blood. Troponin I in small amount persists in Cytosolic pool (the same site of creatine kina...
متن کاملNegative interference in cardiac troponin I immunoassays by circulating troponin autoantibodies.
BACKGROUND There are numerous potential sources of interference in immunoassays. Our aim was to identify the blood component that causes negative interference in cardiac troponin I (cTnI) immunoassays based on antibodies against the central part of cTnI. METHODS We isolated an interfering factor (IF) from a sample with low recovery of added cTnI, using several consecutive purification steps: ...
متن کاملComparison of cardiac troponin I immunoassays variably affected by circulating autoantibodies.
BACKGROUND We recently provided evidence that circulating autoantibodies against cardiac troponin I (cTnI) or the troponin complex cause negative interference in cTnI immunoassays. By comparing three cTnI immunoassays, we further explored the phenomenon of circulating autoantibodies and their consequences in patient samples. METHODS We developed a cTnI immunoassay with a novel assay design us...
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Introduction: Coping ways with stress in coronary heart disease patients can lead to significant changes in levels of Cardiac Biomarker Troponin I, but researchers had not explored it empirically. So, the main objective of this study was to identify the relationship between coping ways with stress and Cardiac Biomarker Troponin I and also, finding coping ways that predict changes in the concent...
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There have been few studies on the immune response to myocardial damage and their findings are of little practical value. Even in myocardial infarction (MI), the classic example of myocardial injury not due to inflammation or infection, the clinical impact of research is limited. An example of what we would hope for from such research, with potential application to clinical practice, is the rec...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 42 12 شماره
صفحات -
تاریخ انتشار 1996